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intrauterine insemination (iui)

intrauterine insemination (iui) is another popular infertility treatment, but success rates are generally low. the success rate for a single iui cycle is around 5-10%, while the success of a single ivf cycle can be as high as 50-60%. legacy fertility clinics may push dozens of iui cycles on patients before moving on to ivf. at mate we want to give you the best and quickest chance at having a baby. the gold standard for infertility care is ivf. often times, people will get frustrated and can waste years and may even pay more money by trying iui cycle after iui cycle. this can also be very tough on your body, as iui cycles still require injectable medication.

ultimately, all decisions on your treatment are up to you. if iui is really the treatment you would like to pursue, having this discussion with your care team will be extremely important. iui can be useful when we find the presence of physical barriers like cervical scarring, poor cervical mucus, or chronic cervical inflammation. erectile dysfunction or moderate sperm abnormalities may also make iui an option.

before iui, we will perform a fertility assessment of both partners. for men, we perform a semen analysis. for women, hormone levels such as anti-mullerian hormone (amh) and follicle stimulating hormone (fsh) are checked, which tells us about egg supply and ovarian function. a physical evaluation and vaginal ultrasound are also performed, and any relevant medical history is discussed. you can find more details under the fertility assessment services.

undergoing intrauterine insemination usually includes taking medication to stimulate the ovaries to produce eggs, then directly injecting sperm into the uterus at the time of ovulation.

stimulate egg growth

you will begin by taking oral or injectable medication to stimulate the growth and maturation of eggs. medication is usually taken for 8-12 days based on how the ovaries respond to medication. based on monitoring appointments, medications may need to be adjusted. 

ultrasound + blood monitoring

while on injectable medications, ultrasound appointments are needed every few days to monitor the ovaries and egg development. blood tests are also performed to gauge hormone levels related to egg growth and ovarian function. through this testing and monitoring, we ensure everything is progressing safely.

ovulation induced

once a mature egg is present, a patient receives a “trigger shot” that induces ovulation within about 36 hours. 

sperm sample processed

the male partner provides sperm, or a donor sperm sample is thawed, then processed by the laboratory. the sperm sample is “washed” to remove debris and the sperm cells are highly concentrated into a small volume.


the sperm sample is injected into the uterus through a thin, long, flexible catheter. the entire process is painless and quick. sometimes, insemination will be recommended two days in a row, but in most cases, a single well-timed insemination is all that is needed.

follow up + pregnancy test

a week after ovulation, progesterone levels are tested. for some patients, additional hormone support (such as progesterone) may be prescribed to help prepare the uterine lining for pregnancy. 

about two weeks after insemination, you will get a pregnancy test.